Posts Tagged ‘ Medical Research ’

Where you go for information on back pain affects the quality of the information you find. Many sites have a specific agenda to sell a particular drug or treatment. This will bias the information. In that sense, this site is no exception. These articles are in support of a particular drug, but we prefer to put that drug into context and give you as rounded a picture as possible. Although we cannot claim to be independent and therefore offer completely unbiased advice, we hope you will find balance here and a freedom to make up your own minds.

Medical research indicates that up to 80% of adult Americans will experience back pain at some point during their lives. In surveys, the respondents consistently report that pain in the lower back is the most disruptive, not only interfering directly with the ability to work and so earn a living, but also affecting the quality of life by:

  • disturbing sleep;
  • encouraging inactivity and weight gain; and
  • even preventing the enjoyment of sex.

When serious pain strikes, the first reaction is usually a consultation with the primary care doctor. At this point, the bad news is received. Although it is always useful to have the possibility of serious underlying diseases and disorders ruled out, even dedicated specialists using the latest in technology, find it difficult to diagnose a specific cause for every case. This is dissatisfying. But doctors are nevertheless able to offer some help in listing treatment options. If a specific cause for the pain has been identified, the treatment can target that cause and, within the limits of technology and surgical skill, produce an improvement if not a cure. Where the cause is not certain, the choices come down to:

  • medication – there are a wide range of drugs available both on prescription and over-the-counter to control the pain and relieve tense muscles;
  • physical therapy to analyze movement problems and encourage greater mobility through the manipulation of the spine and joints, and the training of muscles;
  • cognitive behavioral therapy to teach coping strategies to improve the quality of life, i.e. to help people achieve the maximum within their physical limitations;
  • complementary and alternative therapies such as chiropractic and acupuncture – more controversial but nevertheless found effective by many people; and
  • specialist medical care for better diagnosis and possible treatment.

The main research conclusions are that practical and hands-on treatment give the best results. This includes both physical and cognitive behavioral therapies. The reason for this preference is the social bond between patient and therapist which improves the mood and encourages a more positive outlook on life. The difficulty, of course, is financial. Many health plans do not include either the professionalized or the alternative therapies. If these cannot be funded out of savings, this forces people into more medical tests and surgical interventions, or restricts them to medications. In this context, flexeril can have an important role. As a drug targeting musculoskeletal disorders, it can relax muscles within the spinal structure and increase mobility. In combination with painkillers and a mixture of rest and exercise, flexeril can often help people recover their quality of life. But if you go down this road, you must commit yourself to exercising. You must maintain muscle tone and build strength. Failing to push yourself into a full range of movement is condemning yourself to stiffen and lose mobility.

In some cultures, the best guess was that the world was flat and that the sun was a kind of torch or fire put there by gods to light the sky and keep us warm. Today, even though scientists have not always had the best of reputations, we have at least managed to prove the world to be roundish and that the Earth orbits the sun. Although this kind of science is interesting in an abstract kind of way, it does not touch individual lives in the same way as, say, medical research. Here concerned scientists may work to understand different diseases or disorders so that more effective treatments can be devised. The work of one team may save the lives of millions over the next decades. It is therefore faintly curious that, for the most part, astronomy is funded by the state and the development of medications is funded by private companies for profit. Common sense should have this the other way round. There is no immediate social benefit from knowing more about the cosmos so what justification is there for spending public money on this research? Equally, there is every benefit for the community at large if more safer and effective treatments are made available. Lives will be saved. The quality of life for those who are injured can be improved. This would seem to be worthy of support out of public funds.

But the current system is to leave it to private interests to decide what to research. If there are only a few people who have this problem or the many are too poor to pay a high retail price, there is no profit to be earned. So no research and development to help them. As a result, millions die from diseases that could be treated. Even when a “good” social purpose is served, the basic research is only done to get the drug or device approved. Once the FDA has given its nod, the spotlight passes on to the next drug in the pipeline. Little is done to follow up on how the drug actually performs once it is let loose into the world. The reason, of course, is that this research could be inconvenient and damage the profitability of the drug. Suppose the research found the drug was killing patients. It would have to be withdrawn and profits would dry up.

It is therefore interesting to see that viagra is probably the most continuously researched drug on the planet. For example, in 2002, there was a piece of meta-research done on 27 sets of clinical trials. This is research which picks the best conducted individual trials and puts all the results together to see if there are any general trends. There have been more than one hundred more trials since then. The conclusion is that viagra is not only safe but also effective in men who suffer erectile dysfunction because of depression, diabetes, heart disease, prostate cancer and spinal cord injuries. It is a shame the same level of interest is not shown in proving other drugs such as Vioxx to be as safe.